| 摘要 |
FIELD: medicine.SUBSTANCE: invention refers to medicine and concerns genetic predisposition to risk of ischemic stroke developing diagnostic technique in patients with atrial fibrillation (AF). Method summary: performing analysis of hemostasis system genes: polymorphism -455G>A of FBG gene, polymorphism 10976G>A of FVII gene, polymorphism -5T>C of GPIβα gene, polymorphism 807C>T of GPIα gene. At that, assigned with 0 %, upon detecting of GG polymorphism -455G>A of FBG gene, AA polymorphism 10976G>A of FVII gene, TT polymorphism -5T>C of GPIβα gene, CC polymorphism 807C>T of GPIα gene. Assigned with 50% upon detecting of GA polymorphism -455G>A of FBG gene, GA polymorphism 10976G>A of FVII gene, TC polymorphism -5T>C of GPIβα gene, CT polymorphism 807C>T of GPIα gene. Assigned with 100 % upon detecting of AA polymorphism -455G>A of FBG gene, GG polymorphism 10976G>A of FVII gene, CC polymorphism -5T>C of GPIβα gene, TT polymorphism 807C>T of GPIα gene. Genetic risk of ischemic stroke development with AF is calculated by formula: (a+b+c+d)/n, where a is percentage corresponding to polymorphism genotype -455G> A of FBG gene, b is percentage corresponding to polymorphism genotype 10976G>A of FVII gene, c is percentage corresponding to polymorphism genotype -5T>C of GPIβα gene, d is percentage corresponding to polymorphism genotype 807C>T of GPIα gene, n is number of studied genotypes; risk is considered to be low at value from 0 to 30 %, average is from 30 to 60 %, high is from 60 % and more.EFFECT: proposed method allows to highlight genetic risk of ischemic stroke development in presence of AF in patient and increase ischemic stroke developing individual prevention quality in given group of patients.1 cl, 5 dwg, 5 tbl, 2 ex |
