TUMOR NECROSIS FACTOR (TNF) BINDING PROTEIN II, ITS PURIFICATION AND ANTIBODIES THERETO

摘要

Tumor Necrosis Factor (TNF) Binding Protein is isolated and substantially purified. It has the ability to inhibit the cytotoxic effect of TNF and/or to maintain it s prolonged beneficial effects. TNF Binding Protein II and salts, functional derivative, precursors and active fractions thereof can be used to antagonize the deleterious effec ts of TNF and to prolong its beneficial effects. Polyclonal and monoclonal antibodies to the TNF Binding Protein II are produced. They may be used as pharmaceutical agents a nd in diagnostic assays.