| 摘要 |
Novel atrial peptides of the formula are disclosed which have useful hypotensive, natriuretic and diuretic activity and in which R1 is selected from hydrogen, AcetylArg, Aha, Arg, Cit, His, Lys, Orn and Ser-Ser; R2 is a sulfur-containing group; R3 is a hydrophobic amino acid or dipeptide; R4 is a dipeptide spacer, or a tripeptide containing a dipeptide spacer plus a basic amino acid residue; R5 is a hydrophobic amino acid; R6 is a peptide of up to three amino acids; R7 is selected from Cha, Phe, Cha-Arg, Phe-Arg, (D)Phe-Arg, Phe-(D)Arg, Phe?Arg, Leu-Arg, Ala-Arg, Arg and Gly-Ala; and R8 is a sulfur-containing group, as well as pharmaceutically acceptable salts, esters and amides thereof.
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