| 摘要 |
HA468 GEMINALLY SUBSTITUTED THIAHETEROCYCLIC CARBOXYLIC ACIDS AND DERIVATIVES THEREOF Novel thromboxane receptor antagonists are disclosed, having the formula I wherein: A is aryl, optionally substituted with halogen, lower alkoxy, carboalkoxy, lower alkyl, alkylamino, or phenyl; X is -CH2 or -NH; R1 is COOH, COO-alkali metal (such as Na, K, or Li), COO-lower alkyl, CONHSO2R2, or 5-tetrazolyl; R2 is lower alkyl or aryl; m is 0, 1, or 2; and p is 2, 3, 4 or 5. Also disclosed are novel intermediates of formula I compounds.
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