| 摘要 |
<p>In accordance with the present invention an improved process for preparing resolved compounds of the formula <CHEM> being the cis(+) isomer, is disclosed, wherein R1 and R2 are each independently hydrogen, halogen, alkyl, alkoxy, aryloxy, arylalkoxy, diarylalkoxy, arylalkyl, cyano, hydroxy, alkanoyloxy, -O- @-NX1X2, fluoro substituted alkoxy, fluoro substituted alkyl, (cycloalkyl)alkoxy, -NO2, NX3x4, -S(O)malkyl, -S(O)maryl, - @-X5, or -O-@-X6; m is 0, 1 or 2; X1 and X2 are each independently hydrogen, alkyl, aryl or heteroaryl, or X1 and X2 together with the nitrogen atom to which they are attached are pyrrolidinyl, piperidinyl or morpholinyl; X3 and X4 are each independently hydrogen, alkyl, alkanoyl, arylcarbonyl, heteroarylcarbonyl, or - @-NX1X2; X5 is hydroxy, alkoxy, aryloxy, amino, alkylamino or dialkylamino; and X6 is alkyl, alkoxy or aryloxy; with the proviso that if R4 is a 7-alkyl group, it must have a tertiary carbon atom bonded to the ring.</p> |
