COMBINED USE OF N-IMIDAZOLYL DERIVATIVES OF BICYCLIC COMPOUNDS AND CYCLOSPORINE IN THERAPY

摘要

COMBINED USE OF N-IMIDAZOLYL DERIVATIVES OF BICYCLIC COMPOUNDS AND CYCLOSPORIN IN THERAPY The invention relates to the use of N-imidazolyl derivatives of bicyclic compounds of general formula (I) wherein a) wherein Y completes a single bond or is oxygen or a -CH2- group and the symbol represents a single or double bond or (b) is and the symbol --- represents a double bond; one of R1, R2, R3 and R4 is -CH2OH, C2-C4 acyl, , -COOR7, -CHCOOR7, , or in which each of R7, R8 and R9 is independently hydrogen or C1-C4 alkyl, and the others are independently chosen from hydrogen, hydroxy, halogen, C1-C4 alkyl, C1-C4 alkoxy and -COOR7 wherein R7 is as defined above; and one of R5 and R6 is hydrogen and the other is hydrogen C1-C6 alkyl or phenyl; or a pharmaceutically acceptable salt thereof, in particular in combination with cyclosporin A. The compounds obtained are useful in preventing and/or treating cyclosporin Ainduced nephrosis in mammals.