PIEZOELECTRIC CELL GROWTH BIOSENSING METHOD AND SYSTEM

摘要

2064188 9101381 PCTABS00003 The invention relates to a piezoelectric biosensor device and also to a method and a system utilizing a piezoelectric biosensor device for detecting metabolic growth requirements, antibiotic responses, and the specific bacterial products of microorganisms. When a microorganism is grown in an appropriate nutrient medium containing a metabolite-responsive polymer, metabolic products of the organism acidify the medium and precipitate a polymer/metabolite complex which desposits or accumulates on the surface of a piezoelectric biosensor device. The mass change on the surface of the device resulting from this deposit produces a change in the resonant frequency of the piezoelectric biosensor device which can be used to determine the growth and type of microorganism.