FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES

摘要

DNA coding for at least one enzyme that causes the accumulation of a pyrimidine deoxyribonucleoside is used, in con- junction with metabolic mutations or heterologous DNA coding for metabolic enzymes that also increase pyrimidine deoxyribon- ucleoside production, to engineer cultured cells to express a pyrimidine deoxyribonucleoside (PdN) in recoverable quantities, pro- viding a commercially useful fermentation source for PdNs.