RECEPTOR ASSAY FOR FK-506

摘要

A competitive receptor assay for FK-506 and biologically-active metabolites, derivatives and analogues thereof is dis- closed, wherein the binding reagent is a specific FK-506 receptor protein either purified from the soluble cytoplasm of target cells of FK-506 action, particularly normal or transformed lymphocytes, freshly collected or in established cell lines, or synthesized by recombinant DNA techniques. Solution phase and solid state assay systems are disclosed.