发明名称 |
7-ACYL-3-(SUBSTITUTED CARBAMOYLOXY) CEPHEM COMPOUNDS AND PROCESS FOR THEIR PREPARATION |
摘要 |
A 7-acyl-3-substituted carbamoyloxy cephem compound represented by the following formula (1): <IMGS> wherein: A means a -CH= or -N= group: R1 denotes a hydroxyl, lower alkoxyl, or protected hydroxyl group: R2 and R3 are the same or different and individually represent a lower alkyl, hydroxyl-substituted lower alkyl, a carbamoyl-substituted lower alkyl group or cyano-substituted lower alkyl group, R2 is a hydrogen atom and R3 is a lower alkoxyl or alkyl group optionally substituted by ~ one or more halogen atoms, or the group means a 4-6 membered heterocyclic group, which contains one nitrogen atom, or a morpholino group, said hetero-cyclic group or morpholino group being optionally substituted by one or more lower alkyl, hydroxyl and/or hydroxyl-substituted lower alkyl groups; and R4 denotes a carboxyl or protected carboxyl group: or a pharmaceutically acceptable salt thereof: and a process for the preparation thereof: as well as an antibacterial composition containing the above cephem compound.
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申请公布号 |
CA2054895(A1) |
申请公布日期 |
1992.05.10 |
申请号 |
CA19912054895 |
申请日期 |
1991.11.04 |
申请人 |
EISAI CO., LTD. |
发明人 |
NEGI, SHIGETO;YAMANAKA, MOTOSUKE;KATSU, KANEMASA;SUGIYAMA, ISAO;KOMATU, YUUKI;KAMATA, ATSUSHI;TSURUOKA, AKIHIKO;MACHIDA, YOSHIMASA |
分类号 |
A61K31/545;A61K31/546;A61P31/04;C07D;C07D501/00;C07D501/04;C07D501/06;C07D501/18;C07D501/26;C07D501/28;C07D501/34;C07D501/36 |
主分类号 |
A61K31/545 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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