| 主权项 |
1. An neuregulin noncompetitive allosteric anti-human-HER3 antibody comprising a heavy chain wherein a variable domain comprises:
a H-CDR1 having at least 90% or 95% identity with sequence set forth as SEQ ID NO: 2, a H-CDR2 having at least 90% or 95% identity with sequence set forth as SEQ ID NO: 3, a H-CDR3 having at least 90% or 95% identity with sequence set forth as SEQ ID NO: 4, a L-CDR1 having at least 90% or 95% identity with sequence set forth as SEQ ID NO: 6, a L-CDR2 having at least 90% or 95% identity with sequence set forth as SEQ ID NO: 7, a L-CDR3 having at least 90% or 95% identity with sequence set forth as SEQ ID NO: 8, wherein the neuregulin noncompetitive allosteric anti-human-HER3 antibody specifically binds to HER3 with substantially the same affinity as an antibody comprising a heavy chain wherein the variable domain comprises SEQ ID NO: 2 for H-CDR1, SEQ ID NO: 3 for H-CDR2 and SEQ ID NO: 4 for H-CDR3 and a light chain wherein the variable domain comprises SEQ ID NO: 6 for L-CDR1, SEQ ID NO: 7 for L-CDR2 and SEQ ID NO: 8 for L-CDR3. |
