| 主权项 |
1. A method of increasing erythopoiesis in a human subject, the method comprising administering a trap, and antibody or an antibody fragment that binds a human TMPRSS6 encoded by a TMPRSS6 nucleotide sequence comprising a SNP selected from the group consisting of:
rs855791, rs2543519, rs2235324 and rs1421312;wherein the trap, antibody or antibody fragment comprises a constant region selected from the group consisting of:
(a) a human gamma-4 heavy chain constant region that comprises a Leu at position 189 shown in SEQ ID NO: 73 or an Arg at position 289 shown in SEQ ID NO: 73; and (b) a human gamma-1 heavy chain constant region that comprises an Asp corresponding to position 204 of SEQ ID NO: 42 or a Leu corresponding to position 206 of SEQ ID NO: 42; andwherein
(i) the human subject comprises a TMPRSS6 nucleotide sequence comprising said selected SNP; and (ii) the human subject comprises a constant region gene segment encoding said selected constant region; or the human subject expresses antibodies comprising said selected constant region. |
