发明名称 |
USE OF A LOW AFFINITY-HEPARIN FRACTION IN CONJUNCTION WITH T-PA FOR THROMBOLYTIC THERAPY |
摘要 |
A composition for thrombolytic therapy includes a tissue-type plasminogen activator (t-PA) and a low affinity heparin fraction. The composition is administered intravenously to allow the t-PA to dissolve blood clots while the low affinity heparin fraction prevents reocculsion without the harmful side effects observed for unfractionated heparin, such as, stimulation of and interference with t-PA activity in the circulatory system, as well as, interference with fibrinolytic activity which can cause hemorrhaging in the mammalian circulatory system.
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申请公布号 |
US5130143(A) |
申请公布日期 |
1992.07.14 |
申请号 |
US19880267499 |
申请日期 |
1988.11.04 |
申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK |
发明人 |
STRICKLAND, SIDNEY;ANDRADE-GORDON, PATRICIA |
分类号 |
A61K38/49;C08B37/00 |
主分类号 |
A61K38/49 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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