| 摘要 |
There are disclosed complexes and compositions for oral delivery of a substance or substances to the circulation or lym- phatic drainage system of a host. The complexes of the invention comprise a microparticle coupled to at least one carrier, the car- rier being capable of enabling the complex to be transported to the circulation or lymphatic drainage system via the mucosal ep- ~ ithelium of the host, and the microparticle entrapping or encapsulating, or being capable of entrapping or encapsulating, the substance(s). Examples of suitable carriers are mucosal binding proteins, bacterial adhesins, viral adhesins, toxin binding subun- its, lectins, Vitamin B12, and analogues or derivatives of Vitamin B12 possessing binding activity to Castle's intrinsic factor.
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