| 摘要 |
Substituted 3-(Pyridinylamino)-indoles and benzo[b]thiophenes a process for their preparation and their use as medicaments The present invention relates to compounds of the formula I (see formula I) where R1 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, aminoloweralkyl, loweralkylaminoloweralkyl, formyl, loweralkylcarbonyl, aminoloweralkylcarbonyl or loweralkoxycarbonyl; the group -X-Y= is <IMGS>, R2 and R3 being independently hydrogen or loweralkyl; W is hydrogen, halogen, hydroxy, loweralkoxy, arylloweralkoxy or , where R4 is hydrogen, loweralkyl or arylloweralkyl; R5 is loweralkyl or arylloweralkyl; or alternatively the group <IMGS> R6 being hydrogen, loweralkyl, aryl or arylloweralkyl; and Z is hydrogen, halogen, loweralkyl, nitro or amino; which are useful for alleviating various memory dysfunctions such as Alzheimer's disease, as modulators of neurotransmitter functions such as serotonergic an d adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorders.
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