| 摘要 |
This invention pertains to the synthesis and use as therapeutic agents of a group of substances with a glycerol backbone or aliphatic chain structure linked to a phosphorus atom and a polar head group. Depending on the polar head group, the substance has anti-cancer, anti-inflammatory, anti-allergy or anti-cardiovascular disease properties. Compounds of formulas (I) and (II), wherein n is O to 14 and R1 is an alkyl group of C12-C20, R2 is a methyl group, and wherein R3 is an inositol analog head group, a (CH2)mN<+>(CH3)3 group with m = 2 to 10, a serine head group, or an ethanolamine head group, or of formula (III), wherein R1 and R2 are as described above, n = 0 or 1, and R3 is (CH2)mN<+>(CH3)3 (m=2-10) are claimed. This invention also pertains to the synthesis and use as therapeutic agents of a group of substances that have no glycerol backbone but have an aliphatic chain structure linked directly to a phosphorus atom of the general formula R-P(0)(0<->)OR' wherein R is a long-chain alkyl group such as hexadecyl or octadecyl and R' is a head group such as choline, glycerol, inositol, ethanolamine, or serine. |
