| 摘要 |
<p>The present invention discloses a separating and purifying (4R, 6R)-4-hydroxy-2,2,6-trimethyl cyclohexanone comprising the steps of: reacting a diastereomer mixture of (4R, 6R)-4-hydroxy-2,2,6-trimethyl cyclohexanone represented by the formula (I) <CHEM> and (4S, 6R)-4-hydroxy-2,2,6-trimethyl cyclohexanone represented by the formula (II) <CHEM> with a reagent which reacts with the hydroxyl groups at least equimolar to the compound represented by the formula (II) to thereby convert the compound represented by the formula (II) into a (4S, 6R)-4-hydroxy-2,2,6-trimethyl cyclohexanone derivative represented by the formula (III) <CHEM> (where R represents a group modifying the hydroxyl group) by predominantly modifying the hydroxyl group in the formula (II), and separating the compound of the formula (I) from the compound of the formula (III) through the difference of the solubility in water or an organic solvent. According to the invention, (4R, 6R)-4-hydroxy-2,2,6-trimethyl cyclohexanone is easily separated with a high yield.</p> |
