STEREOSELECTIVE PRODUCTION OF HYDROXYAMIDE COMPOUNDS FROM CHIRAL –-AMINO EPOXIDES

摘要

80/CSQ29 18474 TITLE OF THE INVENTION STEREOSELECTIVE PRODUCTION OF HYDROXYAMIDE COMPOUNDS FROM CHIRAL .alpha.-AMINO EPOXIDES An efficient process for stereoselective preparation of a medicinally significant hydroxyamide compound of structural formula: comprises the addition of metalated amide enolates to chiral .alpha.-amino metalated epoxides. The hydroxyamide reaction products are useful as inhibitors of the HIV protease or of renin, or as intermediates in the preparation of inhibitors of the HIV protease or renin.