| 摘要 |
<p>A pharmaceutical compound of the formula: <CHEM> in which R<1> is C7-20 alkyl, C7-20 alkenyl or C7-20 alkynyl, the alkyl, alkenyl or alkynyl group being optionally substituted by phenyl or substituted phenyl and the alkenyl and alkynyl groups containing 1 to 3 unsaturated bonds, R<2> is (i) optionally substituted phenyl, (ii) C1-10 alkyl optionally substituted by one or more substituents selected from optionally protected hydroxyl, optionally protected carboxyl, nitrile, optionally protected tetrazolyl, -COR<4> where R<4> is C1-4 alkyl, C1-4 alkoxy, an optionally protected amino acid residue or -NR5_2 where each R<5> is hydrogen or C1-4 alkyl, and -NHR<6> where R<6> is hydrogen, a protecting group, an optionally protected amino acid residue, C1-4 alkyl or -COR<7> where R<7> is C1-4 alkyl or C1-4 alkoxy, or (iii) C1-10 alkyl substituted with a group selected from <CHEM> where each R<8> is hydrogen or C1-4 alkyl, and R<3> is hydrogen, carboxyl, C2-5 alkoxycarbonyl, C1-4 alkyl, C1-4 alkoxy, hydroxyl, optionally protected tetrazolyl, halo, trifluoromethyl, nitrile, nitro and -CONR9_2 where each R<9> is hydrogen or C1-4 alkyl; and salts thereof.</p> |
