| 摘要 |
FIELD: pharmaceutics.SUBSTANCE: invention relates to a controlled-release pharmaceutical composition for oral administration. Pharmaceutical composition comprises ciprofloxacin hydrochloride as an active principle. Method for preparation comprises a) granulating the first part of ciprofloxacin and water, b) granulating remaining part of said active ingredient with hydroxypropyl methylcellulose having low molecular weight and water, c) mixing ethyl cellulose and water, d) mixing the granulated material produced at step b) with the ethyl cellulose mixture in a fluidized bed, d) combining both granulated materials with a diluent-binding agent, diluent and sliding substance, e) compacting the produced material. Polymer coating is being optionally applied on a tablet . Also described is a pharmaceutical composition produced using said method. Tablets are characterized in that one part of the ciprofloxacin is released immediately, while another part of the active principle is located in a polymer diffusion matrix system, that allows the active principle to be released in a delayed manner.EFFECT: ciprofloxacin release profile allows administrating ciprofloxacin once a day.6 cl, 1 dwg, 6 tbl |
