PRODUCTION OF .BETA.-FORM THIAMINE HYDROCHLORIDE CRYSTALS

摘要

A method of producing .beta.-form thiamine hydrochloride crystals which comprises moistening .alpha.form thiamine hydrochloride crystals in the presence of .beta.-form thiamine hydrochloride crystals as seed crystals and stirring the mixture and a method of producing pharmaceutical preparations containing .beta.-form thiamine hydrochloride crystals which comprises moistening .alpha.form thiamine hydrochloride crystals, together with a binder, with water in the presence of .beta.-form thiamine hydrochloride crystals as seed crystals and stirring the mixture. .beta.-Form thiamine hydrochloride crystals which are stable and resistant to caking and pharmaceutical preparations containing the same can be produced in a simple and easy manner.