发明名称 |
THIOETHER CONJUGATES |
摘要 |
CT-2135 Provided are drug/ligand compounds of Formula (I): (I) in which D is a drug moiety; n is an integer from 1 to 10; p is an integer from 1 to 6; Y is O or NH2+C1-; z is 0 or 1; q is about 1 to about 10; X is a ligand; and, A is a Michael Addition Adduct. In a preferred embodiment, the ligand is an immunoglobulin, preferably a chimeric antibody or fragment thereof. Also provided are formulations comprising as an active ingredient a compound of Formula (I), intermediates useful for preparing the compounds of Formula (I), processes for preparing the compounds of Formula (I), and methods for using the compounds of the invention. |
申请公布号 |
CA2087286(A1) |
申请公布日期 |
1993.07.24 |
申请号 |
CA19932087286 |
申请日期 |
1993.01.14 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
WILLNER, DAVID;TRAIL, PAMELA A.;KING, H. DALTON;HOFSTEAD, SANDRA J.;GREENFIELD, ROBERT S.;BRASLAWSKY, GARY R. |
分类号 |
A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61K31/7042;A61K31/7048;A61K39/395;A61K47/48;A61P35/00;A61P35/04;C07G11/00;C07H15/252;C07H17/04;C07K1/113;C07K14/00;C07K14/42;C07K14/485;C07K14/495;C07K14/52;C07K14/54;C07K14/55;C07K14/575;C07K14/62;C07K14/65;C07K14/705;C07K16/00;C07K19/00;(IPC1-7):C07H15/252;C07D519/04;C07H15/26;C07H19/04;C07K14/47 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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