| 发明名称 |
RECOMBINANT HUMAN HIV-NEUTRALIZING MONOCLONAL ANTIBODIES FOR PREVENTION AND TREATMENT OF HIV INFECTION |
| 摘要 |
73/JWW31 18709 TITLE OF INVENTION RECOMBINANT HUMAN HIV-NEUTRALIZING MONOCLONAL ANTIBODIES FOR PREVENTION AND TREATMENT OF HIV INFECTION Recombinant human immunoglobulin molecules neutralizing for HIV-1, methods of production of the immunoglobulins and methods of preventing HIV-1 infection using the immunoglobulins are disclosed. DNA constructs containing the complementarity determining regions (CDRs) and framework (FRs) of the native human antibody are combined with other constant regions, and expressed in recombinant host cells. These recombinant antibodies are useful for the treatment and prevention of HIV-1 infection in vivo.
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| 申请公布号 |
CA2093099(A1) |
申请公布日期 |
1993.10.02 |
| 申请号 |
CA19932093099 |
申请日期 |
1993.03.31 |
| 申请人 |
MERCK & CO., INC.;JOHNSON, L. SYD;PFARR, DAVID S. |
发明人 |
EMINI, EMILIO A.;CONLEY, ANTHONY J.;MARK, GEORGE E.;JOHNSON, L. SYD;PFARR, DAVID S. |
| 分类号 |
A61K39/395;A61K38/00;A61P31/12;C07K1/22;C07K14/00;C07K16/00;C07K16/10;C12N5/10;C12N15/02;C12N15/13;C12P21/02;C12P21/08;C12R1/91;(IPC1-7):C12N15/13;C12N1/21;A61K39/42;C07K16/42;C12N15/70;C12N15/85 |
主分类号 |
A61K39/395 |
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