| 摘要 |
<p>PURPOSE:To provide the new trifluorolactic acid aldehyde precursor useful as an intermediate for synthesizing physiologically active substances such as medicines and agricultural chemicals, functional compounds such as liquid crystals and surfactants, etc. CONSTITUTION:A new trifluorolactic acid aldehyde precursor of formula I (F is linear, branched or cyclic alkyl which may contain a heterogeneous atom or a multiple bond, (substituted)aromatic; A is a protecting group containing a secondary hydroxyl group; X is halogen), e.g. 2-acetyloxy-1-chloro-1- phenylthio-3,3,3-trifluoropropane. The compound of formula I is obtained by reacting a trifluoroisopropanol derivative of formula II with a halogenating agent. An optically active compound having an asymmetric center on the methine carbon atom bonded to both the trifluoromethyl group and the OH group protected with the protecting group A is especially preferable as the trifluoroisopropanol derivative of formula II.</p> |
