| 摘要 |
Compounds of formula (I) and pharmaceutical compositions containing the compounds of formula (I): a substituted or unsubstituted aromatic or heterocyclic group; R is H or a substituted or unsubstituted straight or branched chain, cyclic or mixture of straight branched and cyclic alkyl, alkenyl, or alkynyl group having from 1-20 carbon atom; A is a functional group that bears a polar moiety; R1 is R, R-C=0, R substituted with one or more heteroatoms, a substituted or unsubstituted aryl group, or is aryl-(CH2)n; R2 is (CH2)n, CHR, C(R)2, COO, OCO, NHCO, CONH, SO, SO2 or NR; R3 and R4, which are the same or different or each may be absent, and are =O, H, O-aryl, OR, O-alkyl or alkyl, aryl, SR, S-aryl, NHR, NH-aryl, NR, or are other heteroaromatic groups; R5 is H, OH or R; E and F, which are the same or are different, are either N or (CH2)p; p is an integer or 0 between 0 and 5; m and n are integers or 0 between 0 and 10; T is O, S, NCOR or NR; U and V, which may be the same or different, are (CH2)n; W is CO, (CH2)n, (CH2)n-CHR or CHR-(CH2)n; X and Y, which may be the same or different, are H, alkyl or aryl or X and Y form a saturated or unsaturated homocyclic or heterocyclic ring contain 3-15 members; and Z is H, SR, NHR or N(R)2. |
