| 摘要 |
<p>An injection cartridge of the dual-chamber type having a front chamber (2) for a solid component (11) and a rear chamber (3) for a liquid component (5) of an injectable preparation, said chambers being separated by a front piston (4), is provided with a constriction (8) of the cartridge barrel (1) close in front of the front piston (4). The front piston (4) is prevented by the constriction (8), from being inadvertently displaced forward, but on application of an increased force, may be urged into and through the constriction (8) while overcoming the resistance offered by the constriction (8). Said constriction (8) has such a shape that the barrel (1) of the cartridge has a noncircular cross section at the place of the constriction (8), and the front piston (4) will be deformed when it passes through the constriction (8), such that a bypass connection for liquid from the rear chamber (3) to the front chamber (2) is established. A method for manufacturing an injectable preparation of a pharmaceutically active agent for storage in the injection cartridge.</p> |
