| 摘要 |
The present invention relates to a process for inhibition of the enzyme topoisomerase I, which involves contact of said enzyme with an inhibitory amount of a camptothecin selected from the group which consists of 9-amino-20(RS)- camptothecin, 9-amino-20(S)-camptothecin, 10-amino-20(RS)- camptothecin, 10-amino-20(S)-camptothecin, 10,11- methylenedioxy-20(RS)-camptothecin, 10,11-methylenedioxy- 20(S)-camptothecin, sodium salt of 10,11-methylenedioxy- 20(RS)-camptothecin, sodium salt of 10,11-methylenedioxy- 20(S)-camptothecin, and mixtures thereof. The invention also relates to the process for preparation of pharmaceutical compositions containing the aforesaid compounds as the active compound, which are useful in the inhibition process of the invention.
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