COMPOSITION AND METHODS FOR THE GENERATION OF BONE

摘要

Compositions and methods utilizing TGF- beta and demineralized bone matrix are described that are capable of inducing the formation of useful, non-resorptive bone. Bone formation is stimulated by the synergistic activity of a TGF- beta molecule, such as TGF- beta 1 or TGF-5 beta , with a HCl-treated demineralized bone matrix. Normal, hard non-resorptive bone development is stimulated and can be utilized in the treatment of fractures, skeletal defects, surgical repairs and skeletal reconstructions, such as in maxillofacial reconstructions.