GUANIDINE DERIVATIVES AS INHIBITORS OF Na<+>/H<+> EXCHANGE IN CELLS

摘要

Guanidine derivatives of formula (I), wherein Y is N or C-R<1> (in which R<1> is hydrogen, lower alkyl, hydroxy, protected hydroxy, etc.), R<2> is hydrogen, aryl which may have one suitable substituent, aryloxy, etc., R<3> is hydrogen, lower alkoxy, hydroxy, protected hydroxy, etc., Z is N or C-R<4> (in which R<4> is hydrogen, carboxy, protected carboxy, nitro, halogen, hydroxy(lower)alkyl, etc.), and W is N or C-R<12> (in which R<12> is hydrogen, lower alkoxy, nitro, hydroxy or protected hydroxy), and pharmaceutically acceptable salts thereof which are useful as a medicament.