摘要 |
<p>Spirocycles of general structural formulae (I) or (II) wherein: X is O, CH2 or SOm; R1 is AlkylSO¿2?NH-, AlkylO-, AlkylSO2-, AlkylCONH-, or NO2-; R?2¿ is -H, -OAlkyl, or -Alkyl; R3 is -NHCOCH¿2?SOmPhenyl, -NHCOCH2SOmAlkyl, or NHSO2Alkyl; R?4 and R5¿ are -H, or -Alkyl; R6 is (a), (b), (c), (d), (e), (f), (g), (h), or (i); R7 is -H, -CN, -NHSO¿2?Alkyl, -Br, -OAlkyl, -NH2, -NO2, -NHCOalkyl, or NHCONHAlkyl; R?8¿ is -H, -OH, -CN, -OAlkyl, -CONHAlkyl, -NHSO¿2?Alkyl, -NHCOAlkyl, -SOmAlkyl, or -CO2Alkyl; and m is 0-2; or a pharmaceutically acceptable salt, hydrate or crystal form thereof; which are Class III antiarrhythmic agents.</p> |