Fremgangsmåde til enzymatisk adskillelse af 2-amino-4-methylphosphinosmørsyrederivater

摘要

L-PTC (L-phosphinothricin, L-2-amino-4-methylphosphinobutyric acid) is the active herbicidal component in D,L-PTC and can be obtained according to the invention by treating D,L-PTC derivatives which are N-acylated and esterified on the phosphinic acid group, as well as optionally esterified or amidated on the carboxyl group, with an enzyme with hydrolytic activity in aqueous or aqueous-organic medium, whereupon the L-PTC derivatives are selectively hydrolysed at the N-acyl group or the modified carboxyl group, the resulting product mixture is separated, and the required L-PTC derivative is hydrolysed to L-PTC and isolated by customary methods.