4-Aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines

摘要

4-Aryl-1-(indanmethyl, dibydrobenzofuramethyl or dihydrobenzotbiophenemethyl) piperidine, -tetrabydropyridine or -piperazine compounds of general formula (I) wherein one of X and Y is CH2, and the other one is CH2, O or S; Z is N, C, CH or COH; Ar is an optionally substituted aryl group; R1 >is hydrogen, alkyl, cycloalkyl, cycloakylalkyl, aryl, arylalkyl, acyl, thioacyl, alkylsulfonyl, trifloromethylsulfonyl, arylsulfonyl, a group R9>VCO- where V is O or S and R9 >is alkyl or aryl, or a group R10>R11>NCO or R10>R11>NCS- wherein R10 >and R11 >are hydrogen, alkyl or aryl, or R10 >and R11 >are linked to form a ring R2 >is hydrogen, alkyl, cycloalkyl or cycloalkylalkyl; or R1 >and R2 >are linked to form a ring; R3>—R5 >are hydrogen, halogen, alkyl, alkylcarbonyl, phenylcarbonyl, alkoxy, alkylthio, hydroxy, alkylsulfonyl, cyano, trifluoromethyl, cycloalkyl, cycloalkylaLkyl or nitro; R6 >and R7 >are bydrogen or alkyl or they are linked to constitute a 3-7-membered ring; R8 >is hydrogen or alkyl; have effects at central serotonergic receptors and are therefore useful in the treatment of certain psychic and neurologic disorders.