| 摘要 |
<p>Described herein are muscarinic receptor-selective compounds of Formula (I), wherein: A and B are independently selected, optionally substituted, unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is selected from O, S, SO, SO2, C=O, CH2, CH-OH, CH-NEt2, C=CHCI, C=CHCN, NH, N-C1-4alkyl and N-acetyl; X2--- is selected from N=, CH2-, CH= and C(O)-; n is 1 or 2; and Z is selected from C1-6alkyl optionally substituted with a substituent selected from OH, halo, C1-4alkyl, C1-4alkoxy and phenyl; and acid addition salts, solvates and hydrates thereof. Their use as ligands for dopamine receptor identification and in a drug screening program, and as pharmaceuticals to treat indications in which the M1/M2 receptor is implicated, such as schizophrenia, are also described.</p> |
