发明名称 |
1,8-Naphthyridin-2-one derivatives |
摘要 |
<p>Disclosed are naphthyridine derivatives represented by formula (I) <CHEM> wherein: X represents hydrogen; lower alkyl; aralkyl; substituted or unsubstituted aryl; substituted or unsubstituted aromatic heterocyclic group; -NR<1>R<2> wherein R<1> and R<2> independently represent hydrogen or lower alkyl; <CHEM> wherein W represents N or CH, Z represents a single bond, oxygen or NR<3> (wherein R<3> represents hydrogen, lower alkyl or benzyl) and n1 and n2 represent an integer of 1 to 3; or substituted or unsubstituted thiazolinyl; and Y is a single bond or alkylene and pharmaceutically acceptable salts thereof. The compounds show potent anti-inflammatory activity and are expected to be useful in treating rheumarthritis.</p> |
申请公布号 |
GR3020848(T3) |
申请公布日期 |
1996.11.30 |
申请号 |
GR19960402205T |
申请日期 |
1996.08.22 |
申请人 |
KYOWA HAKKO KOGYO CO., LTD. |
发明人 |
SUZUKI, FUMIO;KURODA, TAKESHI;OHMORI, KENJI;TAMURA, TADAFUMI;HOSOE, HISASHI |
分类号 |
A61K31/435;A61K31/00;A61K31/4353;A61K31/4375;A61K31/44;A61K31/4427;A61K31/444;A61K31/495;A61K31/4965;A61K31/497;A61K31/535;A61K31/5375;A61K31/5377;A61P29/00;A61P37/00;A61P37/08;C07D471/04;(IPC1-7):C07D471/04 |
主分类号 |
A61K31/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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