| 摘要 |
<p>PROBLEM TO BE SOLVED: To obtain a medicinal composition, containing a tripeptide having a specific amino acid sequence or its salt as an active ingredient and extremely rarely causing dangerousness of developing adverse effects due to its carcinostatic effects and ability to hydrolyze into amino acids which are metabolized in living bodies. SOLUTION: This medicinal composition contains a tripeptide of the formula, Pro-A-B (A is phenylalanine, lysine, etc.; B is proline or tryptophan) or its salt as an active ingredient. The objective composition is preferably administered in a daily dose of 0.01-10g for an adult in one or several divided portions. Furthermore, the tripeptide is usually prepared by mutually condensing protected amino acids using a condensing agent such as dicyclohexylcrbodiimide in a solid or a liquid phase method according to the amino acid sequence. Protecting groups of the resultant tripeptide are removed by a trifluoromethanesulfonic acid method, etc.</p> |
