| 摘要 |
PROBLEM TO BE SOLVED: To obtain a safe antitumor agent exhibiting excellent antitumor action on malignant tumor and causing little side actions. SOLUTION: This agent contains >=0.01wt.% of 3-[4-hydroxy-3,5-bis(3-methyl-2- butenyl)phenyl]-2-propenoic acid of formula (X is a cation) or its salt as an active component. It can be administered by oral or parenteral administration at a daily dose of 10μm to 10mg, preferably 10μg to 1mg for adult in 1-4 or 1-5 divided doses. The agent exhibits remarkable antitumor action on solid cancers such as colon cancer, rectal cancer, gastric cancer, thyroid cancer, lingual cancer, bladder cancer, chorionic carcinoma, hepatic cancer, uterine cancer, prostate cancer, laryngeal cancer, pulmonary cancer, mammary cancer, malignant melanoma, Kaposi's sarcoma, cerebral tumor, neuroblastoma, ovarian tumor, testicular tumor, osteogenic sarcoma, pancreatic cancer, renal cancer, hypernephroma and hemangioendothelioma and corpuscular malignant tumors such as leukemia and lymphoma. |
