| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new DNA for production, etc., of a human CRF2 receptor protein having a specific base sequence and useful for a primer, etc., for polymerase chain reaction of DNA coding a G protein conjugated receptor protein. SOLUTION: This new DNA has substantially same base sequence as a base sequence represented by formula I or II and is useful as a DNA primer, etc., used for polymerase chain reaction of DNA coding a G protein-conjugated receptor protein. This human CRF2 receptor protein is obtained by expressing a gene cloned by polymerase chain reaction using the DNA as a primer. The receptor protein is useful for screening an agonist such as a preventing and treating agent for dementia or obesity or a hypotensive agent and an antagonist for prevention and treatment, etc., of depression, inflammatory diseases, AIDS, Alzheimer's disease, gastrointestinal injury, reproductive failure, Cushing's disease, hypotension, etc. |
