| 摘要 |
<p>Methods and devices for dissociating multimeric proteins and their delivery to patients, along with resultant compositions, are provided. A monomeric protein delivery device is also provided, comprising a supply of a multimeric protein (4) complex, comprising multimeric protein and an aggregating agent; a flow path having a subcutaneous exit (8), fluidly coupling the multimeric protein supply to the exit; a porous surface assembly situated along the flow path comprising a porous surface (10); and an aggregating agent binding partner carried by the surface (12); whereby the aggreagating agent of the multimeric protein complex passing along the surface is bound to the binding partner on the surface to create a monomeric protein flow through the subcutaneous exit.</p> |
