| 摘要 |
The present invention relates to compounds of formula I: (See Formula); wherein: R1 is a 2-RA-3-RB-phenyl radical, a 2-RA-4-Rc-phenyl radical, a 2-RA-pyridine-3-yl radical, a 3-RA-pyridine-2-yl radical, or a 1-RD-indol-3-yl radical, wherein: a first RA and RB radicals is an aliphatic or heterocycloaliphatic-aliphatic radical, or free or aliphatically, araliphatically, or heteroaliphatically sterified hydroxy, and the other is hydrogen, an aliphatic radical or free or sterified or amidated carboxy, Rc is hydrogen, and a second aliphatic radical, free or aliphatically, araliphatically, or heteroaliphatically sterified hydroxy, or an unsubstituted or heteroaliphatically substituted amino group, and RD is an aliphatic, araliphatic, or heteroaliphatic radical, one of X1 and X2 radicals is carbonyl and the other is methylene, R2 is an aliphatic radical, R3 is unsubstituted or aliphatically substituted amino, R4 is an aliphatic or araliphatic radical, R5 is an aliphatic or cycloaliphatic-aliphatic radical, or a heteroaryl radical optionally hydrogenated and/or oxo-substituted, or a heteroaryl or heteroaliphatic radical optionally hydrogenated and/or oxo-substituted linked by a carbon atom, and salts thereof, having renin-inhibiting properties, and can be utilized as medicaments anti-hypertensive active ingredients.
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