PRODUCTION OF SUSTAINED RELEASE PHARMACEUTICAL PREPARATION OF ADENOCORTICOTROPIC HORMONE DERIVATIVE

摘要

PROBLEM TO BE SOLVED: To obtain the subject preparation capable of carrying out longterm zero-dimensional release of an adrenocorticotropic hormone derivative useful as a peptide of psychotropic nerve action by using a drying method in water from an emulsion using lactic acid-glycolic acid having a composition ratio in a specific range and a weight-average molecular weight in a specific range. SOLUTION: A W/O type emulsion using (A) a solution or a dispersion containing an adrenocorticotropic hormone derivative [preferably L-methionyl-L- glutamyl-L-histidyl-L-phenylalanyl-D-lysyl-N-(8-aminooctyl)-L-phenylal anineamide- S, S-dioxide] or its salt (preferably acetic salt) as an inner water phase and using (B) a solution containing an in vivo degradable polymer having a free carboxyl group at the end as an oil phase is prepared. Then, the resultant emulsion is dispersed into an outer water phase to prepare a W/0/W type emulsion, which is then dried by drying in water. Furthermore, the outer water phase contains preferably 0.1-60(W/V)% osmotic pressure adjuster (preferably mannitol).