| 摘要 |
A kit for detecting a nucleotide sequence of interest with signal amplification, containing a labelled nucleotide probe and a reagent essentially including a suspension of particles on which at least one series of oligonucleotide units is immobilised. Each of the series of oligonucleotide units, which are all identical, includes, at least, a nucleotide sequence hybridizable with said sequence of interest and a nucleotide sequence hybridizable with said probe. Said reagent contains more than 10 such oligonucleotide units per particle. The kit is particularly useful for diagnosing genetic diseases or determining pathogens such as bacteria, viruses, fungi or parasites.
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