SUBSTITUTED TETRACYCLIC TETRAHYDROFURAN DERIVATIVES

摘要

This invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, wherein n is zero to 6; p and q are zero to 4; r is zero to 5; R?1 and R2¿ each independently are hydrogen; optionally substituted C¿1-6?alkyl; C1-6alkylcarbonyl; halomethylcarbonyl; or R?1 and R2¿ taken together with the nitrogen atom to which they are attached may form a morpholinyl ring or an optionally substituted heterocycle; each R?3 and R4¿ independently are halo, cyano, hydroxy, halomethyl, halomethoxy, carboxyl, nitro, amino, mono- or di(C¿1-6?alkyl)amino, C1-6alkylcarbonylamino, aminosulfonyl, mono- or di(C1-6alkyl)aminosulfonyl, C1-6alkyl, C1-6alkyloxy, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl; each R?5¿ independently is C¿1-6?alkyl, cyano or halomethyl; X is CR?6R7, NR8¿, O, S, S(=O) or S(=O)¿2?; aryl is optionally substituted phenyl; provided that the compound is other than (±)-3,3a,8,12b-tetrahydro-N-methyl-2H-dibenzo[3,4:6,7]-cyclohepta[1,2-b]-furan-2-methanamine oxalic acid. The compounds of formula (I) may be used as therapeutic agents in the treatment or the prevention of CNS disorders, cardiovascular disorders or gastrointestinal disorders.