NEW AZOLIDINEDIONES AS ANTIHYPERGLYCEMIC AGENTS.

摘要

This invention relates to novel compounds which have demonstrated oral antihyperglycemic activity in diabetic ob/ob and db/db mice, animal models on non-insulin dependent diabetes mellitus (NIDDM or Type II diabetes). These compounds have formula (I), wherein: R1 is C1-C6 alkyl, C3-C8 cycloalkyl, thienyl, furyl, pyridyl, (a) or (b), where R10 is hydrogen, C1-C6 alkyl, fluorine, chlorine, bromine, iodine, C1-C6 alkyoxy, trifluoroalkyl or trifluoroalkoxy; R2 is hydrogen or C1-C6 alkyl; X is O or S; n is 0, 1, or 2; A is (c) or (d); where R3 is hydrogen, C1-C6 alkyl, halogen, C1-C6 alkoxy, trifluoroalkyl or trifluoroalkoxy; B is (e), (f) or (g), where R4 is hydrogen, C1-C6 alkyl, allyl, C6-C10 aryl, C6-C10 aryl-(CH2)1-6-, fluorine, chlorine, bromine, iodine, trimethylsilyl or C3-C8 cycloalkyl; R5 is hydrogen, C1-C6 alkyl, C6-C10 aryl, or C6-C10 aryl-(CH2)1-6-; m is 0, 1, or 2; R6 is hydrogen or C1-C6 alkyl; R7 is hydrogen or C1-C6 alkyl; R8 and R9 are selected independently from hydrogen, C1-C6 alkyl, fluorine, chlorine, bromine, or iodine; Y is O or S; Z is N or CH when Y is O and Z is CH when Y is S; or a pharmaceutically acceptable salt thereof.