| 摘要 |
<p>The present invention relates to isolated or recombinant nucleic acids (DNA, RNA) which encode a latheo protein. The nucleic acids of the present invention include nucleic acids encoding human latheo protein (SEQ ID NO. 1), fly latheo protein (SEQ ID NO. 3) and characteristic portions thereof. The invention also relates to isolated or recombinantly produced latheo protein. For example, the latheo protein can be human latheo protein (SEQ ID NO. 4), fly latheo protein (SEQ ID NO. 2) and functional portions thereof. Also encompassed by the present invention is an agent which interacts with latheo directly or indirectly, and inhibits or enhances latheo function. The present invention further relates to a method of detecting latheo protein in a sample (e.g., blood, cerebral spinal fluid) obtained from an individual (e.g., human). The present invention further relates to a method of modulating dopamine levels in a mammal, comprising administering to the mammal an agent which interacts with latheo.</p> |
