| 摘要 |
<p>DC-89 derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein (a) represents (b) or (c); Y represents hydrogen, halogeno, optionally substituted lower alkyl, COR?1, CH=NR8¿ or (d); Z represents hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted aryl, optionally substituted heterocycle or COR9 (wherein R represents hydrogen, COR?12 or R16R17R18¿Si; and V represents hydrogen, halogeno, nitro or COR11); W represents hydrogen, (e), (f), (g) or (h); and X represents Cl or Br, provided that when Y is hydrogen or CO¿2R?2 (wherein R2 is hydrogen, linear or branched C¿1-4? alkyl, aryl or benzyl), then Z and V do not represent hydrogen at the same time. These compounds have excellent antitumor activities, which makes them useful as antitumor agents.</p> |
