| 摘要 |
FIELD: chemical industry. SUBSTANCE: novel aryl condensed 2,4- diazepine compounds of formula I: <EMI ID=0.55 HE=33 WI=36 TI=CHI> wherein A is napthyl, phenyl, unsubstituted or substituted by halogen, nitro, lower alkyl or alkoxy; R is H, lower alkyl or phenyl; R is H, lower alkyl, cyclopropyl (lower alkyl, benzyl, phenyl, unsubstituted or substituted by lower alkoxy; or -CH<SB>2</SB>CH<SB>2</SB>R wherein R is lower alkoxy, di(lower) alkylamino or morpholino; R is Y<SB>p</SB>-(CH<SB>2</SB>)<SB>m</SB>-X<SB>n</SB>-R wherein J is NH-, - S-, -O- or -CH(CH<SB>3</SB>), p=0 or 1, m=0-7, n= 0-1; A is -S-, -O-, O<SB>2</SB> or -CH=CH; R is H, lower alkyl, phenyl, pyridinyl optionally substituted by lower alkyl; phenyl with 1 or 2 substituents selected from halogen, lower alkyl, lower alkoxy, lower alkyl sulfonamide, di(lower)alkyl aminosulfonyl; R is H, lower alkyl or lower alkoxyalkyl; <EMI ID=0.56 HE=9 WI=3 TI=CHI> is H, lower alkyl, benzyl, phenyl optionally substituted by halogen or lower alkoxy, or naphthyl. Said compounds have antiarrythmic activity. Antiarrythmic agent is used in combination with pharmaceutically acceptable solvent or filler in composition for treating heart arrythmia. The present invention describes novel intermediate compounds: <EMI ID=0.57 HE=60 WI=51 TI=CHI> wherein R is H, lower alkyl or phenyl; R is H, phenyl optionally substituted by halogen or lower alkoxy, or napthyl; R is halogen or condensed benzene ring: R is H, lower alkyl, benzyl or di(lower)alkylamino (lower) alkyl; R is H, lower alkyl, phenyl optionally substituted by halogen, lower alkyl, lower alkoxy, lower alkyl sulfonamide, or pyridinyl unsubstituted or substituted by lower alkyl; n is 0 or 1; R is lower alkyl, benzyl, phenyl optionally substituted by lower alkoxy; or CH<SB>2</SB>CH<SB>2</SB>R in which R is lower alkoxy, di(lower)alkylamino or morpholino; R is H, benzyl, naphthyl, phenyl optionally substituted by halogen, lower alkoxy. Said compounds are used for synthesizing compounds of general formula I.
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