7beta--[(Z)-2-(2-AMINO-4-THIAZOLYL)-2-HYDROXYIMINOACETAMIDO]-3- -(1,2,3-TRIAZOLE-4-YL)-THIOMETHYLTHIO-3-CEPHEM-4-CARBOXYLIC ACID HYDROCHLORIDE, ITS CRYSTAL HYDRATE AND METHOD OF THEIR SYNTHESIS

摘要

FIELD: organic chemistry and technology, antibiotics. SUBSTANCE: invention proposes 7beta--[(Z)-2-(2-amino-4-thiazolyl)-2-hydroxyiminoacetamido] -3- -(1,2,3-triazole-4-yl)-thiomethylthio-3-cephem-4-carboxylic acid hydrochloride and its crystal hydrates that show strong antibiotic activity and pharmaceutical stability and can be used as active components of clinically useful antibiotic compositions and methods of their synthesis. EFFECT: improved method of synthesis. 6 cl, 2 tbl, 16 ex, 2 dwge