| 摘要 |
A composition (I) comprises: (A) an immunogenic agent derived from Helicobacter; and (B) at least one adjuvant chosen from (i) purified saponins from an extract of Quillaja saponaria; (ii) cationic lipids (or their salts) which are weak inhibitors of protein kinase C and have a structure including a lipophilic group derived from cholesterol, a carboxamide or carbamoyl linking group, a spacer arm consisting of a 1-20C alkyl chain and a cationic amine group (primary, secondary, tertiary or quaternary), provided that the lipids are not present in the form of liposomes when (I) contains neither (i) nor (ii); and (iii) glyco-lipo-peptides of formula (II). R1 = 1-50C alkyl (optionally unsaturated); X = -CH2-, -O- or -NH-; R2 = H or as R1; R3-R5 = H or acyl-CO-R6; R6 = 1-10C alkyl; R7 = H, 1-7C alkyl, hydroxymethyl, 1-hydroxyethyl, mercaptomethyl, 2-(methylthio)-ethyl, 3-aminopropyl, 3-ureido-propyl, 3-guanidylpropyl, 4-aminobutyl, carboxymethyl, carbamoylmethyl, 2-carboxyethyl, 2-carbamoylethyl, benzyl, 4-hydroxybenzyl, 3-indolylmethyl or 4-imidazolylmethyl; R8 = H or methyl; R9 = H, acetyl, benzoyl, trichloroacetyl, trifluoroacetyl, methoxycarbonyl, t-butoxycarbonyl or benzyloxycarbonyl;or R7 + R8 = -(CH2)3- .
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