1,2,3,3A,8,8A-HEXAHYDRO-1,3A-8-TRIMETHYLPYRROLO-[2,3-B]-INDOLE TETRAHYDROISOQUINOLINE CARBAMATES, PHARMACEUTICAL COMPOSITION AND METHOD OF ACETYLCHOLINE ESTERASE INHIBITION

摘要

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention describes 1,2,3,3a, 8,8a-hexahydro-1,3a-8-trimethylpyrrolo- -[2,3-b]-indole tetrahydroisoquinoline carbamates of the formula (I) <EMI ID=0.81 HE=36 WI=72 TI=CHI> where R - hydrogen, lower alkyl; X - hydrogen, or their acceptable acid-additive salts. Invention proposes also a pharmaceutical composition and a method of inhibition of acetylcholine esterase activity using the claimed compounds. Synthesized compounds can be used in patients with memory disfunction and with cholinergic deficiency. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 9 cl, 2 ex, 1 tbl