DERIVATIVES OF AMINOASCORBIC ACID AND METHODS OF THEIR SYNTHESIS AND DERIVATIVES OF HALOIDASCORBIC ACID

摘要

FIELD: organic chemistry, vitamin derivatives. SUBSTANCE: invention proposes derivatives of aminoascorbic acid of the formula (I) where R' is H, C1-C8-alkyl, CH2R3; R'' is C2-C8-alkyl, CH2R3, or when R' means H then R'' means -C(O)H; R is 5- or 6-membered heterocycle containing oxygen, nitrogen or sulfur atom as a heteroatom, C1-C8-alkyl, C6-C12-aryl or cyclohexyl; R,R1,R2 are H, benzyl. These compounds show anticarcinogenic effect. Compounds of the formula (I) are synthesized by different methods, in part, by alkylation of a compound of the formula (II) . EFFECT: improved methods of synthesis, enhanced antitumor activity of compounds.